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Week 11: San Francisco 49ers 41, Arizona Cardinals 22

Published On: November 17, 2025

49ers Dominate Cardinals With Balanced Attack

In Week 11, the San Francisco 49ers defeated the visiting Arizona Cardinals 41–22, showcasing both offensive versatility and a disciplined defense. Quarterback Brock Purdy orchestrated the offense effectively, mixing short passes, play-action, and a dominant running game to control the tempo.

Arizona tried to respond with quarterback Kyler Murray, who connected on several deep throws, but the 49ers’ secondary limited yards after catch and forced turnovers that stymied momentum.

Implications

San Francisco’s balanced attack and defensive discipline reinforce their position as NFC contenders. Arizona will need adjustments in quarterback protection and red-zone execution to remain competitive.

Looking Ahead

The 49ers can carry momentum forward, confident in both offensive and defensive execution. The Cardinals must refine their attack to close scoring gaps in upcoming matchups.

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