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Week 12: San Francisco 49ers 35, Arizona Cardinals 28

Published On: November 28, 2025

49ers Edge Cardinals in Offensive Shootout

San Francisco defeated Arizona 35–28 in a game full of scoring swings. Quarterback Brock Purdy threw for three touchdowns, and the defense made critical stops in the red zone.

Arizona’s offense produced big plays but failed to sustain drives consistently in the second half. Special teams contributed to field position that helped the 49ers maintain control.

Implications

The 49ers showcase offensive efficiency and clutch defense, while the Cardinals must convert opportunities and reduce turnovers to remain competitive.